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BIOINFORMATICS
2011
15 years 1 months ago
2011
Motivation: Over the recent years, the vision that RNA simply serves as information transfer molecule has dramatically changed. The study of the sequence/structure/function relati...
212
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BMCBI
2011
15 years 1 months ago
2011
Background: As one of the most widely used parsimony methods for ancestral reconstruction, the Fitch method minimizes the total number of hypothetical substitutions along all bran...
168
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BMCBI
2011
15 years 1 months ago
2011
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
215
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BMCBI
2011
15 years 1 months ago
2011
Background: Next-generation sequencing technologies allow genomes to be sequenced more quickly and less expensively than ever before. However, as sequencing technology has improve...
204
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BMCBI
2011
15 years 1 months ago
2011
Background: Recently we have witnessed a surge of interest in using genome-wide association studies (GWAS) to discover the genetic basis of complex diseases. Many genetic variatio...