22018 search results - page 4358 / 4404 » or 2004 |
205
click to vote
BMCBI
2004
15 years 6 months ago
2004
Background: The function of a novel gene product is typically predicted by transitive assignment of annotation from similar sequences. We describe a novel method, GOtcha, for pred...
170
click to vote
BMCBI
2004
15 years 6 months ago
2004
Background: A key step in the analysis of microarray expression profiling data is the identification of genes that display statistically significant changes in expression signals ...
167
click to vote
BMCBI
2004
15 years 6 months ago
2004
Background: Microarray data must be normalized because they suffer from multiple biases. We have identified a source of spatial experimental variability that significantly affects...
182
click to vote
BMCBI
2004
15 years 6 months ago
2004
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
181
click to vote
BMCBI
2004
15 years 6 months ago
2004
Background: The rapidly increasing number of completely sequenced genomes led to the establishment of the COG-database which, based on sequence homologies, assigns similar protein...