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BMCBI
2005
113views more  BMCBI 2005»
15 years 6 months ago
Alternative splicing and protein function
Background: Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alter...
A. D. Neverov, Irena I. Artamonova, Ramil N. Nurtd...
BMCBI
2005
147views more  BMCBI 2005»
15 years 6 months ago
GATA: a graphic alignment tool for comparative sequence analysis
Background: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved se...
David A. Nix, Michael B. Eisen
BMCBI
2005
97views more  BMCBI 2005»
15 years 6 months ago
Evolutionary distance estimation and fidelity of pair wise sequence alignment
Background: Evolutionary distances are a critical measure in comparative genomics and molecular evolutionary biology. A simulation study was used to examine the effect of alignmen...
Michael S. Rosenberg
BMCBI
2005
93views more  BMCBI 2005»
15 years 6 months ago
Multiple sequence alignment accuracy and evolutionary distance estimation
Background: Sequence alignment is a common tool in bioinformatics and comparative genomics. It is generally assumed that multiple sequence alignment yields better results than pai...
Michael S. Rosenberg
BMCBI
2005
107views more  BMCBI 2005»
15 years 6 months ago
ProbeMaker: an extensible framework for design of sets of oligonucleotide probes
Background: Procedures for genetic analyses based on oligonucleotide probes are powerful tools that can allow highly parallel investigations of genetic material. Such procedures r...
Johan Stenberg, Mats Nilsson, Ulf Landegren