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BMCBI
2006
118views more  BMCBI 2006»
15 years 6 months ago
Low degree metabolites explain essential reactions and enhance modularity in biological networks
Background: Recently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes an...
Areejit Samal, Shalini Singh, Varun Giri, Sandeep ...
BMCBI
2006
160views more  BMCBI 2006»
15 years 6 months ago
Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources
Background: In order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons an...
Mario Stanke, Oliver Schöffmann, Burkhard Mor...
BMCBI
2006
112views more  BMCBI 2006»
15 years 6 months ago
Phylophenetic properties of metabolic pathway topologies as revealed by global analysis
Background: As phenotypic features derived from heritable characters, the topologies of metabolic pathways contain both phylogenetic and phenetic components. In the post-genomic e...
Yong Zhang, Shaojuan Li, Geir Skogerbø, Zhi...
BMCBI
2006
111views more  BMCBI 2006»
15 years 6 months ago
PepDist: A New Framework for Protein-Peptide Binding Prediction based on Learning Peptide Distance Functions
Background: Many different aspects of cellular signalling, trafficking and targeting mechanisms are mediated by interactions between proteins and peptides. Representative examples...
Tomer Hertz, Chen Yanover
BMCBI
2006
133views more  BMCBI 2006»
15 years 6 months ago
Choosing negative examples for the prediction of protein-protein interactions
The protein-protein interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experim...
Asa Ben-Hur, William Stafford Noble