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BMCBI
2006
223views more  BMCBI 2006»
15 years 6 months ago
PSMIX: an R package for population structure inference via maximum likelihood method
Background: Inference of population stratification and individual admixture from genetic markers is an integrative part of a study in diverse situations, such as association mappi...
Baolin Wu, Nianjun Liu, Hongyu Zhao
BMCBI
2007
116views more  BMCBI 2007»
15 years 6 months ago
Linear array of conserved sequence motifs to discriminate protein subfamilies: study on pyridine nucleotide-disulfide reductases
Background: The pyridine nucleotide disulfide reductase (PNDR) is a large and heterogeneous protein family divided into two classes (I and II), which reflect the divergent evoluti...
César L. Avila, Viviana A. Rapisarda, Ricar...
BMCBI
2007
216views more  BMCBI 2007»
15 years 6 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
BMCBI
2007
78views more  BMCBI 2007»
15 years 6 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
BMCBI
2007
123views more  BMCBI 2007»
15 years 6 months ago
Normalization and experimental design for ChIP-chip data
Background: Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been widely used to investigate the DNA binding sites for a variety of proteins on a genome-wide scale. ...
Shouyong Peng, Artyom A. Alekseyenko, Erica Larsch...