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BMCBI
2010
125views more  BMCBI 2010»
15 years 6 months ago
Asymmetric microarray data produces gene lists highly predictive of research literature on multiple cancer types
Background: Much of the public access cancer microarray data is asymmetric, belonging to datasets containing no samples from normal tissue. Asymmetric data cannot be used in stand...
Noor B. Dawany, Aydin Tozeren
BMCBI
2007
107views more  BMCBI 2007»
15 years 6 months ago
Reuse of structural domain-domain interactions in protein networks
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...
Benjamin Schuster-Böckler, Alex Bateman
BMCBI
2007
123views more  BMCBI 2007»
15 years 6 months ago
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
Zailong Wang, Pearlly Yan, Dustin P. Potter, Chari...
BMCBI
2007
135views more  BMCBI 2007»
15 years 6 months ago
LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise
Background: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separat...
Dante Mantini, Francesca Petrucci, Damiana Pierago...
BMCBI
2007
147views more  BMCBI 2007»
15 years 6 months ago
Statistical significance of quantitative PCR
Background: PCR has the potential to detect and precisely quantify specific DNA sequences, but it is not yet often used as a fully quantitative method. A number of data collection...
Yann Karlen, Alan McNair, Sébastien Persegu...
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