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BMCBI
2010
165views more  BMCBI 2010»
15 years 6 months ago
Bayesian integrated modeling of expression data: a case study on RhoG
Background: DNA microarrays provide an efficient method for measuring activity of genes in parallel and even covering all the known transcripts of an organism on a single array. T...
Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arja...
BMCBI
2010
154views more  BMCBI 2010»
15 years 6 months ago
An eScience-Bayes strategy for analyzing omics data
Background: The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge da...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
BMCBI
2010
97views more  BMCBI 2010»
15 years 6 months ago
Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear a
Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Maris Lapinsh, Jarl E. S. Wikberg
BMCBI
2010
112views more  BMCBI 2010»
15 years 6 months ago
A boundary delimitation algorithm to approximate cell soma volumes of bipolar cells from topographical data obtained by scanning
Background: Cell volume determination plays a pivotal role in the investigation of the biophysical mechanisms underlying various cellular processes. Whereas light microscopy in pr...
Patrick Happel, Kerstin Moller, Ralf Kunz, Irmgard...
BMCBI
2010
158views more  BMCBI 2010»
15 years 6 months ago
Validation of differential gene expression algorithms: Application comparing fold-change estimation to hypothesis testing
Background: Sustained research on the problem of determining which genes are differentially expressed on the basis of microarray data has yielded a plethora of statistical algorit...
Corey M. Yanofsky, David R. Bickel