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BMCBI
2010
15 years 6 months ago
2010
Background: Natively unfolded proteins lack a well defined three dimensional structure but have important biological functions, suggesting a re-assignment of the structure-functio...
157
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BMCBI
2010
15 years 6 months ago
2010
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E. coli to id...
135
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BMCBI
2010
15 years 6 months ago
2010
Background: Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. H...
159
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BMCBI
2010
15 years 6 months ago
2010
Background: Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restriction...
149
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BMCBI
2010
15 years 6 months ago
2010
Background: The budding yeast Saccharomyces cerevisiae is one of the most widely studied model organisms in aging-related science. Although several genetic modifiers of yeast long...