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BMCBI
2010
104views more  BMCBI 2010»
15 years 6 months ago
Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies
Background: All polypeptide backbones have the potential to form amyloid fibrils, which are associated with a number of degenerative disorders. However, the likelihood that amyloi...
Maria Pamela C. David, Gisela P. Concepcion, Eduar...
BMCBI
2010
150views more  BMCBI 2010»
15 years 6 months ago
Automatic structure classification of small proteins using random forest
Background: Random forest, an ensemble based supervised machine learning algorithm, is used to predict the SCOP structural classification for a target structure, based on the simi...
Pooja Jain, Jonathan D. Hirst
BMCBI
2010
101views more  BMCBI 2010»
15 years 6 months ago
Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...
Zhengdong D. Zhang, Mark B. Gerstein
BMCBI
2010
96views more  BMCBI 2010»
15 years 6 months ago
The Protein-DNA Interface database
The Protein-DNA Interface database (PDIdb) is a repository containing relevant structural information of Protein-DNA complexes solved by X-ray crystallography and available at the...
Tomás Norambuena, Francisco Melo
BMCBI
2010
130views more  BMCBI 2010»
15 years 6 months ago
Analysis of DNA strand-specific differential expression with high density tiling microarrays
Background: DNA microarray technology allows the analysis of genome structure and dynamics at genome-wide scale. Expression microarrays (EMA) contain probes for annotated open rea...
Luis Quintales, Mar Sánchez, Francisco Ante...