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BMCBI
2004
2004
Improving the scaling normalization for high-density oligonucleotide GeneChip expression microarrays
15 years 6 months ago
Background: Normalization is an important step for microarray data analysis to minimize biological and technical variations. Choosing a suitable approach can be critical. The defa...
166
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BMCBI
2004
15 years 6 months ago
2004
Background: To identify differentially expressed genes across experimental conditions in oligonucleotide microarray experiments, existing statistical methods commonly use a summar...
162
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BMCBI
2004
15 years 6 months ago
2004
Background: It is well known that different species have different protein domain repertoires, and indeed that some protein domains are kingdom specific. This information has not ...
167
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BMCBI
2004
15 years 6 months ago
2004
Background: Existing sequence alignment algorithms assume that similarities between DNA or amino acid sequences are linearly ordered. That is, stretches of similar nucleotides or ...
169
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BMCBI
2004
15 years 6 months ago
2004
Background: Mutations in rpoB, the gene encoding the subunit of DNA-dependent RNA polymerase, are associated with rifampin resistance in Mycobacterium tuberculosis. Several studi...