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BMCBI
2006
75views more  BMCBI 2006»
15 years 6 months ago
Improving the specificity of high-throughput ortholog prediction
Background: Orthologs (genes that have diverged after a speciation event) tend to have similar function, and so their prediction has become an important component of comparative g...
Debra L. Fulton, Yvonne Y. Li, Matthew R. Laird, B...
BMCBI
2006
101views more  BMCBI 2006»
15 years 6 months ago
Predicting residue contacts using pragmatic correlated mutations method: reducing the false positives
Background: Predicting residues' contacts using primary amino acid sequence alone is an important task that can guide 3D structure modeling and can verify the quality of the ...
Petras J. Kundrotas, Emil Alexov
BMCBI
2006
128views more  BMCBI 2006»
15 years 6 months ago
New directions in biomedical text annotation: definitions, guidelines and corpus construction
Background: While biomedical text mining is emerging as an important research area, practical results have proven difficult to achieve. We believe that an important first step tow...
W. John Wilbur, Andrey Rzhetsky, Hagit Shatkay
BMCBI
2006
118views more  BMCBI 2006»
15 years 6 months ago
Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...
BMCBI
2006
112views more  BMCBI 2006»
15 years 6 months ago
Argument-predicate distance as a filter for enhancing precision in extracting predications on the genetic etiology of disease
Background: Genomic functional information is valuable for biomedical research. However, such information frequently needs to be extracted from the scientific literature and struc...
Marco Masseroli, Halil Kilicoglu, François-...