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BMCBI
2006
108views more  BMCBI 2006»
15 years 6 months ago
NOXclass: prediction of protein-protein interaction types
Background: Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level. Interpretation of these...
Hongbo Zhu, Francisco S. Domingues, Ingolf Sommer,...
BMCBI
2006
141views more  BMCBI 2006»
15 years 6 months ago
Maximum common subgraph: some upper bound and lower bound results
Background: Structure matching plays an important part in understanding the functional role of biological structures. Bioinformatics assists in this effort by reformulating this p...
Xiuzhen Huang, Jing Lai, Steven F. Jennings
BMCBI
2006
82views more  BMCBI 2006»
15 years 6 months ago
A method for computing the overall statistical significance of a treatment effect among a group of genes
Background: In studies that use DNA arrays to assess changes in gene expression, our goal is to evaluate the statistical significance of treatments on sets of genes. Genes can be ...
Robert R. Delongchamp, Taewon Lee, Cruz Velasco
BMCBI
2006
118views more  BMCBI 2006»
15 years 6 months ago
Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tis
Background: Aristolochic acid (AA) is the active component of herbal drugs derived from Aristolochia species that have been used for medicinal purposes since antiquity. AA, howeve...
Tao Chen, Lei Guo, Lu Zhang 0013, Leming M. Shi, H...
BMCBI
2006
98views more  BMCBI 2006»
15 years 6 months ago
The Secrets of a Functional Synapse - From a Computational and Experimental Viewpoint
Background: Neuronal communication is tightly regulated in time and in space. The neuronal transmission takes place in the nerve terminal, at a specialized structure called the sy...
Michal Linial