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BMCBI
2004
116views more  BMCBI 2004»
15 years 6 months ago
Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure p
Background: A detailed understanding of an RNA's correct secondary and tertiary structure is crucial to understanding its function and mechanism in the cell. Free energy mini...
Kishore J. Doshi, Jamie J. Cannone, Christian W. C...
BMCBI
2004
126views more  BMCBI 2004»
15 years 6 months ago
Visualising very large phylogenetic trees in three dimensional hyperbolic space
Background: Common existing phylogenetic tree visualisation tools are not able to display readable trees with more than a few thousand nodes. These existing methodologies are base...
Timothy Hughes, Young Hyun, David A. Liberles
BMCBI
2004
75views more  BMCBI 2004»
15 years 6 months ago
Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes
Background: Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very f...
Hongying Jiang, Youping Deng, Huann-Sheng Chen, Li...
BMCBI
2004
90views more  BMCBI 2004»
15 years 6 months ago
Haplotype frequency estimation error analysis in the presence of missing genotype data
Background: Increasingly researchers are turning to the use of haplotype analysis as a tool in population studies, the investigation of linkage disequilibrium, and candidate gene ...
Enda D. Kelly, Fabian Sievers, Ross McManus
BMCBI
2004
89views more  BMCBI 2004»
15 years 6 months ago
Network analysis of metabolic enzyme evolution in Escherichia coli
Background: The two most common models for the evolution of metabolism are the patchwork evolution model, where enzymes are thought to diverge from broad to narrow substrate speci...
Sara Light, Per Kraulis