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BMCBI
2005
120views more  BMCBI 2005»
15 years 6 months ago
A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools
Background: This paper describes a microarray study including data quality control, data analysis and the analysis of the mechanism of toxicity (MOT) induced by 1-methyl-4-phenylp...
Zengjun Xu, Tucker A. Patterson, Jonathan D. Wren,...
BMCBI
2004
77views more  BMCBI 2004»
15 years 6 months ago
Graphical technique for identifying a monotonic variance stabilizing transformation for absolute gene intensity signals
Background: The usefulness of log2 transformation for cDNA microarray data has led to its widespread application to Affymetrix data. For Affymetrix data, where absolute intensitie...
Kellie J. Archer, Catherine I. Dumur, Viswanathan ...
BMCBI
2004
119views more  BMCBI 2004»
15 years 6 months ago
PASS2: an automated database of protein alignments organised as structural superfamilies
Background: The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention of significant sequence similarity between p...
Anirban Bhaduri, Ganesan Pugalenthi, Ramanathan So...
BMCBI
2004
114views more  BMCBI 2004»
15 years 6 months ago
Analysis of superfamily specific profile-profile recognition accuracy
Background: Annotation of sequences that share little similarity to sequences of known function remains a major obstacle in genome annotation. Some of the best methods of detectin...
James A. Casbon, Mansoor A. S. Saqi
BMCBI
2004
96views more  BMCBI 2004»
15 years 6 months ago
GeneOrder3.0: Software for comparing the order of genes in pairs of small bacterial genomes
Background: An increasing number of whole viral and bacterial genomes are being sequenced and deposited in public databases. In parallel to the mounting interest in whole genomes,...
Srikanth Celamkoti, Sashidhara Kundeti, Anjan Purk...