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BMCBI
2007
129views more  BMCBI 2007»
15 years 6 months ago
Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping
Background: The Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping. It is known t...
Michael C. Wendl
BMCBI
2007
89views more  BMCBI 2007»
15 years 6 months ago
Comparing segmentations by applying randomization techniques
Background: There exist many segmentation techniques for genomic sequences, and the segmentations can also be based on many different biological features. We show how to evaluate ...
Niina Haiminen, Heikki Mannila, Evimaria Terzi
BMCBI
2007
102views more  BMCBI 2007»
15 years 6 months ago
Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
BMCBI
2007
119views more  BMCBI 2007»
15 years 6 months ago
Conceptual-level workflow modeling of scientific experiments using NMR as a case study
Background: Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans...
Kacy K. Verdi, Heidi J. C. Ellis, Michael R. Gryk
BMCBI
2007
109views more  BMCBI 2007»
15 years 6 months ago
Computational RNA secondary structure design: empirical complexity and improved methods
Background: We investigate the empirical complexity of the RNA secondary structure design problem, that is, the scaling of the typical difficulty of the design task for various cl...
Rosalía Aguirre-Hernández, Holger H....