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BMCBI
2007
113views more  BMCBI 2007»
15 years 6 months ago
PILER-CR: Fast and accurate identification of CRISPR repeats
Background: Sequencing of prokaryotic genomes has recently revealed the presence of CRISPR elements: short, highly conserved repeats separated by unique sequences of similar lengt...
Robert C. Edgar
BMCBI
2007
237views more  BMCBI 2007»
15 years 6 months ago
FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data
Background: Data clustering analysis has been extensively applied to extract information from gene expression profiles obtained with DNA microarrays. To this aim, existing cluster...
Limin Fu, Enzo Medico
BMCBI
2007
99views more  BMCBI 2007»
15 years 6 months ago
Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Ki
Background: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure ...
Jenny Gu, Philip E. Bourne
BMCBI
2007
136views more  BMCBI 2007»
15 years 6 months ago
Genomorama: genome visualization and analysis
Background: The ability to visualize genomic features and design experimental assays that can target specific regions of a genome is essential for modern biology. To assist in the...
Jason D. Gans, Murray Wolinsky
BMCBI
2007
149views more  BMCBI 2007»
15 years 6 months ago
A unified framework for finding differentially expressed genes from microarray experiments
Background: This paper presents a unified framework for finding differentially expressed genes (DEGs) from the microarray data. The proposed framework has three interrelated modul...
Jahangheer S. Shaik, Mohammed Yeasin