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BMCBI
2006
137views more  BMCBI 2006»
15 years 6 months ago
Chaos game representation for comparison of whole genomes
Background: Chaos game representation of genome sequences has been used for visual representation of genome sequence patterns as well as alignment-free comparisons of sequences ba...
Jijoy Joseph, Roschen Sasikumar
BMCBI
2006
134views more  BMCBI 2006»
15 years 6 months ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
BMCBI
2006
130views more  BMCBI 2006»
15 years 6 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
BMCBI
2006
86views more  BMCBI 2006»
15 years 6 months ago
Identification of QTLs controlling gene expression networks defined a priori
Background: Gene expression microarrays allow the quantification of transcript accumulation for many or all genes in a genome. This technology has been utilized for a range of inv...
Daniel J. Kliebenstein, Marilyn A. L. West, Hans v...
BMCBI
2005
141views more  BMCBI 2005»
15 years 6 months ago
Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
Background: Type 1 diabetes mellitus (T1DM) is a autoimmune disease caused by a long-term negative balance between immune-mediated beta-cell damage and beta-cell repair/regenerati...
Nils E. Magnusson, Alessandra K. Cardozo, Mogens K...