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BMCBI
2006
112views more  BMCBI 2006»
15 years 6 months ago
Protein disorder prediction by condensed PSSM considering propensity for order or disorder
Background: More and more disordered regions have been discovered in protein sequences, and many of them are found to be functionally significant. Previous studies reveal that dis...
Chung-Tsai Su, Chien-Yu Chen, Yu-Yen Ou
BMCBI
2006
132views more  BMCBI 2006»
15 years 6 months ago
Genome-wide DNA polymorphism analyses using VariScan
Background: DNA sequence polymorphisms analysis can provide valuable information on the evolutionary forces shaping nucleotide variation, and provides an insight into the function...
Stephan Hutter, Albert J. Vilella, Julio Rozas
BMCBI
2006
157views more  BMCBI 2006»
15 years 6 months ago
Comparison of protein interaction networks reveals species conservation and divergence
Background: Recent progresses in high-throughput proteomics have provided us with a first chance to characterize protein interaction networks (PINs), but also raised new challenge...
Zhi Liang, Meng Xu, Maikun Teng, Liwen Niu
BMCBI
2006
103views more  BMCBI 2006»
15 years 6 months ago
Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
Background: The identification of differentially expressed genes (DEGs) from Affymetrix GeneChips arrays is currently done by first computing expression levels from the low-level ...
Sébastien Lemieux
BMCBI
2006
139views more  BMCBI 2006»
15 years 6 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana