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BMCBI
2006
165views more  BMCBI 2006»
15 years 6 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig
BMCBI
2006
202views more  BMCBI 2006»
15 years 6 months ago
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks
Background: The learning of global genetic regulatory networks from expression data is a severely under-constrained problem that is aided by reducing the dimensionality of the sea...
David J. Reiss, Nitin S. Baliga, Richard Bonneau
BMCBI
2006
91views more  BMCBI 2006»
15 years 6 months ago
Empirical study of supervised gene screening
Background: Microarray studies provide a way of linking variations of phenotypes with their genetic causations. Constructing predictive models using high dimensional microarray me...
Shuangge Ma
BMCBI
2006
110views more  BMCBI 2006»
15 years 6 months ago
Design of a combinatorial DNA microarray for protein-DNA interaction studies
Background: Discovery of precise specificity of transcription factors is an important step on the way to understanding the complex mechanisms of gene regulation in eukaryotes. Rec...
Julian Mintseris, Michael B. Eisen
BMCBI
2006
105views more  BMCBI 2006»
15 years 6 months ago
CRNPRED: highly accurate prediction of one-dimensional protein structures by large-scale critical random networks
Background: One-dimensional protein structures such as secondary structures or contact numbers are useful for three-dimensional structure prediction and helpful for intuitive unde...
Akira R. Kinjo, Ken Nishikawa