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BMCBI
2006
123views more  BMCBI 2006»
15 years 6 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2006
102views more  BMCBI 2006»
15 years 6 months ago
SNA - a toolbox for the stoichiometric analysis of metabolic networks
Background: Despite recent algorithmic and conceptual progress, the stoichiometric network analysis of large metabolic models remains a computationally challenging problem. Result...
Robert Urbanczik
BMCBI
2006
158views more  BMCBI 2006»
15 years 6 months ago
Detection of non-coding RNAs on the basis of predicted secondary structure formation free energy change
Background: Non-coding RNAs (ncRNAs) have a multitude of roles in the cell, many of which remain to be discovered. However, it is difficult to detect novel ncRNAs in biochemical s...
Andrew V. Uzilov, Joshua M. Keegan, David H. Mathe...
BMCBI
2006
110views more  BMCBI 2006»
15 years 6 months ago
Bias in error estimation when using cross-validation for model selection
Background: Cross-validation (CV) is an effective method for estimating the prediction error of a classifier. Some recent articles have proposed methods for optimizing classifiers...
Sudhir Varma, Richard Simon
BMCBI
2006
171views more  BMCBI 2006»
15 years 6 months ago
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
Roel G. W. Verhaak, Frank J. T. Staal, Peter J. M....