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BMCBI
2006
166views more  BMCBI 2006»
15 years 6 months ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
BMCBI
2006
128views more  BMCBI 2006»
15 years 6 months ago
Lexical adaptation of link grammar to the biomedical sublanguage: a comparative evaluation of three approaches
Background: We study the adaptation of Link Grammar Parser to the biomedical sublanguage with a focus on domain terms not found in a general parser lexicon. Using two biomedical c...
Sampo Pyysalo, Tapio Salakoski, Sophie Aubin, Adel...
BMCBI
2006
114views more  BMCBI 2006»
15 years 6 months ago
A methodology for global validation of microarray experiments
Background: DNA microarrays are popular tools for measuring gene expression of biological samples. This ever increasing popularity is ensuring that a large number of microarray st...
Mathieu Miron, Owen Z. Woody, Alexandre Marcil, Ca...
BMCBI
2006
103views more  BMCBI 2006»
15 years 6 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2006
115views more  BMCBI 2006»
15 years 6 months ago
Detecting recombination in evolving nucleotide sequences
Background: Genetic recombination can produce heterogeneous phylogenetic histories within a set of homologous genes. These recombination events can be obscured by subsequent resid...
Cheong Xin Chan, Robert G. Beiko, Mark A. Ragan