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BMCBI
2006
91views more  BMCBI 2006»
15 years 6 months ago
Cheminformatics methods for novel nanopore analysis of HIV DNA termini
Background: Channel current feature extraction methods, using Hidden Markov Models (HMMs) have been designed for tracking individual-molecule conformational changes. This informat...
Stephen Winters-Hilt, Matthew Landry, Mark Akeson,...
BMCBI
2007
116views more  BMCBI 2007»
15 years 6 months ago
Clustering protein environments for function prediction: finding PROSITE motifs in 3D
Background: Structural genomics initiatives are producing increasing numbers of threedimensional (3D) structures for which there is little functional information. Structure-based ...
Sungroh Yoon, Jessica C. Ebert, Eui-Young Chung, G...
BMCBI
2007
136views more  BMCBI 2007»
15 years 6 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
BMCBI
2007
141views more  BMCBI 2007»
15 years 6 months ago
Using structural motif descriptors for sequence-based binding site prediction
Background: Many protein sequences are still poorly annotated. Functional characterization of a protein is often improved by the identification of its interaction partners. Here, ...
Andreas Henschel, Christof Winter, Wan Kyu Kim, Mi...
BMCBI
2007
138views more  BMCBI 2007»
15 years 6 months ago
A novel Bayesian approach to quantify clinical variables and to determine their spectroscopic counterparts in 1H NMR metabonomic
Background: A key challenge in metabonomics is to uncover quantitative associations between multidimensional spectroscopic data and biochemical measures used for disease risk asse...
Aki Vehtari, Ville-Petteri Mäkinen, Pasi Soin...