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BMCBI
2010
174views more  BMCBI 2010»
15 years 7 months ago
The effect of prior assumptions over the weights in BayesPI with application to study protein-DNA interactions from ChIP-based h
Background: To further understand the implementation of hyperparameters re-estimation technique in Bayesian hierarchical model, we added two more prior assumptions over the weight...
Junbai Wang
BMCBI
2010
142views more  BMCBI 2010»
15 years 7 months ago
pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree
Background: Likelihood-based phylogenetic inference is generally considered to be the most reliable classification method for unknown sequences. However, traditional likelihood-ba...
Frederick A. Matsen III, Robin B. Kodner, E. Virgi...
BMCBI
2010
134views more  BMCBI 2010»
15 years 7 months ago
R-Gada: a fast and flexible pipeline for copy number analysis in association studies
Background: Genome-wide association studies (GWAS) using Copy Number Variation (CNV) are becoming a central focus of genetic research. CNVs have successfully provided target genom...
Roger Pique-Regi, Alejandro Cáceres, Juan R...
BMCBI
2010
151views more  BMCBI 2010»
15 years 7 months ago
Using diffusion distances for flexible molecular shape comparison
Background: Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat t...
Yu-Shen Liu, Qi Li, Guo-Qin Zheng, Karthik Ramani,...
BMCBI
2010
114views more  BMCBI 2010»
15 years 7 months ago
Detecting variants with Metabolic Design, a new software tool to design probes for explorative functional DNA microarray develop
Background: Microorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic poten...
Sébastien Terrat, Eric Peyretaillade, Olivi...
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