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BMCBI
2010
137views more  BMCBI 2010»
15 years 6 months ago
BS Seeker: precise mapping for bisulfite sequencing
Background: Bisulfite sequencing using next generation sequencers yields genome-wide measurements of DNA methylation at single nucleotide resolution. Traditional aligners are not ...
Pao-Yang Chen, Shawn Cokus, Matteo Pellegrini
BMCBI
2010
134views more  BMCBI 2010»
15 years 6 months ago
Localizing triplet periodicity in DNA and cDNA sequences
Background: The protein-coding regions (coding exons) of a DNA sequence exhibit a triplet periodicity (TP) due to fact that coding exons contain a series of three nucleotide codon...
Liya Wang, Lincoln D. Stein
BMCBI
2008
116views more  BMCBI 2008»
15 years 6 months ago
Clustering exact matches of pairwise sequence alignments by weighted linear regression
Background: At intermediate stages of genome assembly projects, when a number of contigs have been generated and their validity needs to be verified, it is desirable to align thes...
Alvaro J. González, Li Liao
BMCBI
2007
116views more  BMCBI 2007»
15 years 6 months ago
Linear array of conserved sequence motifs to discriminate protein subfamilies: study on pyridine nucleotide-disulfide reductases
Background: The pyridine nucleotide disulfide reductase (PNDR) is a large and heterogeneous protein family divided into two classes (I and II), which reflect the divergent evoluti...
César L. Avila, Viviana A. Rapisarda, Ricar...
BMCBI
2005
81views more  BMCBI 2005»
15 years 6 months ago
Evolutionary sequence analysis of complete eukaryote genomes
Background: Gene duplication and gene loss during the evolution of eukaryotes have hindered attempts to estimate phylogenies and divergence times of species. Although current meth...
Jaime E. Blair, Prachi Shah, S. Blair Hedges