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» Using probabilistic model checking in systems biology
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TITB
2002
142views more  TITB 2002»
15 years 6 months ago
Building a bioinformatics ontology using OIL
This paper describes the initial stages of building an ontology of bioinformatics and molecular biology. The conceptualisation is encoded using the Ontology Inference Layer (OIL),...
Robert Stevens, Carole A. Goble, Ian Horrocks, Sea...
CMSB
2009
Springer
16 years 1 months ago
Approximation of Event Probabilities in Noisy Cellular Processes
Molecular noise, which arises from the randomness of the discrete events in the cell, significantly influences fundamental biological processes. Discrete-state continuous-time st...
Frédéric Didier, Thomas A. Henzinger...
BMCBI
2007
142views more  BMCBI 2007»
15 years 6 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
RECOMB
2005
Springer
16 years 6 months ago
Using Multiple Alignments to Improve Gene Prediction
The multiple species de novo gene prediction problem can be stated as follows: given an alignment of genomic sequences from two or more organisms, predict the location and structur...
Samuel S. Gross, Michael R. Brent
GECCO
2005
Springer
180views Optimization» more  GECCO 2005»
16 years 3 days ago
Inference of gene regulatory networks using s-system and differential evolution
In this work we present an improved evolutionary method for inferring S-system model of genetic networks from the time series data of gene expression. We employed Differential Ev...
Nasimul Noman, Hitoshi Iba