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BMCBI
2011
15 years 1 months ago
CODA (CrossOver Distribution Analyzer): quantitative characterization of crossover position patterns along chromosomes
Background: During meiosis, homologous chromosomes exchange segments via the formation of crossovers. This phenomenon is highly regulated; in particular, crossovers are distribute...
Franck Gauthier, Olivier C. Martin, Matthieu Falqu...
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BMCBI
2011
15 years 1 months ago
Systematic error detection in experimental high-throughput screening
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
Plamen Dragiev, Robert Nadon, Vladimir Makarenkov
BMCBI
2011
15 years 1 months ago
Multivariate analysis of microarray data: differential expression and differential connection
Background: Typical analysis of microarray data ignores the correlation between gene expression values. In this paper we present a model for microarray data which specifically all...
Harri T. Kiiveri
BMCBI
2011
15 years 1 months ago
Hierarchical graphs for rule-based modeling of biochemical systems
Background: In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state...
Nathan W. Lemons, Bin Hu, William S. Hlavacek
BMCBI
2011
15 years 1 months ago
Tree Pruner: An efficient tool for selecting data from a biased genetic database
Background: Large databases of genetic data are often biased in their representation. Thus, selection of genetic data with desired properties, such as evolutionary representation ...
Mohan Krishnamoorthy, Pragneshkumar Patel, Mira Di...
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