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BMCBI
2010
179views more  BMCBI 2010»
15 years 7 months ago
A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties
Background: Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited ...
Zhuhong You, Zheng Yin, Kyungsook Han, De-Shuang H...
BMCBI
2010
124views more  BMCBI 2010»
15 years 7 months ago
Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: Transcriptional dynamics and regu
Background: Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both benefici...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
BMCBI
2008
97views more  BMCBI 2008»
15 years 7 months ago
Interrogating domain-domain interactions with parsimony based approaches
Background: The identification and characterization of interacting domain pairs is an important step towards understanding protein interactions. In the last few years, several met...
Katia S. Guimarães, Teresa M. Przytycka
BMCBI
2006
145views more  BMCBI 2006»
15 years 6 months ago
GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
SAT
2010
Springer
165views Hardware» more  SAT 2010»
15 years 5 months ago
An Empirical Study of Optimal Noise and Runtime Distributions in Local Search
This paper presents a detailed empirical study of local search for Boolean satisfiability (SAT), highlighting several interesting properties, some of which were previously unknown...
Lukas Kroc, Ashish Sabharwal, Bart Selman