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BMCBI
2010
116views more  BMCBI 2010»
15 years 6 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
ALMOB
2006
138views more  ALMOB 2006»
15 years 6 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
CORR
2007
Springer
155views Education» more  CORR 2007»
15 years 6 months ago
Low-density graph codes that are optimal for source/channel coding and binning
We describe and analyze the joint source/channel coding properties of a class of sparse graphical codes based on compounding a low-density generator matrix (LDGM) code with a low-...
Martin J. Wainwright, Emin Martinian
BMCBI
2005
115views more  BMCBI 2005»
15 years 6 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
MOBICOM
2006
ACM
16 years 17 days ago
On optimal communication cost for gathering correlated data through wireless sensor networks
In many energy-constrained wireless sensor networks, nodes cooperatively forward correlated sensed data to data sinks. In order to reduce the communication cost (e.g. overall ener...
Junning Liu, Micah Adler, Donald F. Towsley, Chun ...