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BMCBI
2010
100views more  BMCBI 2010»
15 years 6 months ago
A robust method for estimating gene expression states using Affymetrix microarray probe level data
Background: Microarray technology is a high-throughput method for measuring the expression levels of thousand of genes simultaneously. The observed intensities combine a non-speci...
Megu Ohtaki, Keiko Otani, Keiko Hiyama, Naomi Kame...
BMCBI
2007
154views more  BMCBI 2007»
15 years 6 months ago
Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms
Background: Identifying syntenic regions, i.e., blocks of genes or other markers with evolutionary conserved order, and quantifying evolutionary relatedness between genomes in ter...
Amit U. Sinha, Jaroslaw Meller
BMCBI
2010
142views more  BMCBI 2010»
15 years 6 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
BMCBI
2008
105views more  BMCBI 2008»
15 years 6 months ago
Novel computational methods for increasing PCR primer design effectiveness in directed sequencing
Background: Polymerase chain reaction (PCR) is used in directed sequencing for the discovery of novel polymorphisms. As the first step in PCR directed sequencing, effective PCR pr...
Kelvin Li, Anushka Brownley, Timothy B. Stockwell,...
BMCBI
2010
122views more  BMCBI 2010»
15 years 6 months ago
Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional
Background: New technologies are enabling the measurement of many types of genomic and epigenomic information at scales ranging from the atomic to nuclear. Much of this new data i...
Thomas M. Asbury, Matt Mitman, Jijun Tang, W. Jim ...
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