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BMCBI
2010
98views more  BMCBI 2010»
15 years 7 months ago
An optimized TOPS+ comparison method for enhanced TOPS models
nd: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a...
Mallika Veeramalai, David Gilbert, Gabriel Valient...
BMCBI
2010
105views more  BMCBI 2010»
15 years 7 months ago
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement
Background: The Medium-chain Dehydrogenases/Reductases (MDR) form a protein superfamily whose size and complexity defeats traditional means of subclassification; it currently has ...
Joel Hedlund, Hans Jörnvall, Bengt Persson
BMCBI
2008
186views more  BMCBI 2008»
15 years 7 months ago
Variable selection for large p small n regression models with incomplete data: Mapping QTL with epistases
Background: Identifying quantitative trait loci (QTL) for both additive and epistatic effects raises the statistical issue of selecting variables from a large number of candidates...
Min Zhang, Dabao Zhang, Martin T. Wells
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SIAMSC
2008
97views more  SIAMSC 2008»
15 years 6 months ago
Long-Time Simulations on High Resolution Meshes to Model Calcium Waves in a Heart Cell
Abstract. A model for the flow of calcium in an atrial heart cell is given by a system of timedependent reaction-diffusion equations coupled by non-linear reaction terms. Calcium i...
Matthias K. Gobbert
BMCBI
2005
141views more  BMCBI 2005»
15 years 6 months ago
A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models
Background: G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligan...
Nikolaos G. Sgourakis, Pantelis G. Bagos, Panagiot...