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SAC
2005
ACM
16 years 8 days ago
Graphical rule-based representation of signal-transduction networks
The process by which a cell senses and responds to its environment, as in signal transduction, is often mediated by a network of protein-protein interactions, in which proteins co...
James R. Faeder, Michael L. Blinov, William S. Hla...
ECCB
2002
IEEE
15 years 11 months ago
Stochastic roadmap simulation for the study of ligand-protein interactions
The dynamics of ligand-protein interactions are necessary to understand for the design of novel therapeutic agents. In this paper, we establish the use of Stochastic Roadmap Simul...
Mehmet Serkan Apaydin, Carlos Guestrin, Chris Varm...
GI
1997
Springer
15 years 11 months ago
Functional Object-Oriented Programming with Object-Gofer
Object-Gofer is a small, practical extension of the functional programming language Gofer incorporating the following ideas from the object-oriented community: objects and toplevel...
Wolfram Schulte, Klaus Achatz
ALMOB
2008
124views more  ALMOB 2008»
15 years 6 months ago
A scoring matrix approach to detecting miRNA target sites
Background: Experimental identification of microRNA (miRNA) targets is a difficult and time consuming process. As a consequence several computational prediction methods have been ...
Simon Moxon, Vincent Moulton, Jan T. Kim
BMCBI
2008
102views more  BMCBI 2008»
15 years 6 months ago
Stability of the core domain of p53: insights from computer simulations
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...
Arumugam Madhumalar, Derek John Smith, Chandra Ver...