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BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
15 years 7 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
BMCBI
2007
109views more  BMCBI 2007»
15 years 7 months ago
TABASCO: A single molecule, base-pair resolved gene expression simulator
Background: Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavio...
Sriram Kosuri, Jason R. Kelly, Drew Endy
BMCBI
2008
128views more  BMCBI 2008»
15 years 7 months ago
Finding sequence motifs with Bayesian models incorporating positional information: an application to transcription factor bindin
Background: Biologically active sequence motifs often have positional preferences with respect to a genomic landmark. For example, many known transcription factor binding sites (T...
Nak-Kyeong Kim, Kannan Tharakaraman, Leonardo Mari...
BMCBI
2008
143views more  BMCBI 2008»
15 years 7 months ago
Automatic detection of exonic splicing enhancers (ESEs) using SVMs
Background: Exonic splicing enhancers (ESEs) activate nearby splice sites and promote the inclusion (vs. exclusion) of exons in which they reside, while being a binding site for S...
Britta Mersch, Alexander Gepperth, Sándor S...
CORR
2010
Springer
122views Education» more  CORR 2010»
15 years 7 months ago
Facility Location with Client Latencies: Linear-Programming based Techniques for Minimum-Latency Problems
We introduce a problem that is a common generalization of the uncapacitated facility location (UFL) and minimum latency (ML) problems, where facilities not only need to be opened ...
Deeparnab Chakrabarty, Chaitanya Swamy