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BMCBI
2008
109views more  BMCBI 2008»
15 years 6 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
BMCBI
2010
138views more  BMCBI 2010»
15 years 6 months ago
Sigma-2: Multiple sequence alignment of non-coding DNA via an evolutionary model
Background: While most multiple sequence alignment programs expect that all or most of their input is known to be homologous, and penalise insertions and deletions, this is not a ...
Gayathri Jayaraman, Rahul Siddharthan
BMCBI
2010
182views more  BMCBI 2010»
15 years 6 months ago
Beyond co-localization: inferring spatial interactions between sub-cellular structures from microscopy images
Background: Sub-cellular structures interact in numerous direct and indirect ways in order to fulfill cellular functions. While direct molecular interactions crucially depend on s...
Jo A. Helmuth, Grégory Paul, Ivo F. Sbalzar...
BMCBI
2007
104views more  BMCBI 2007»
15 years 6 months ago
Predicting active site residue annotations in the Pfam database
Background: Approximately 5% of Pfam families are enzymatic, but only a small fraction of the sequences within these families (<0.5%) have had the residues responsible for cata...
Jaina Mistry, Alex Bateman, Robert D. Finn
BMCBI
2008
78views more  BMCBI 2008»
15 years 6 months ago
A new protein linear motif benchmark for multiple sequence alignment software
Background: Linear motifs (LMs) are abundant short regulatory sites used for modulating the functions of many eukaryotic proteins. They play important roles in post-translational ...
Emmanuel Perrodou, Claudia Chica, Olivier Poch, To...