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BMCBI
2005
100views more  BMCBI 2005»
15 years 6 months ago
Scoredist: A simple and robust protein sequence distance estimator
Background: Distance-based methods are popular for reconstructing evolutionary trees thanks to their speed and generality. A number of methods exist for estimating distances from ...
Erik L. L. Sonnhammer, Volker Hollich
BMCBI
2005
152views more  BMCBI 2005»
15 years 6 months ago
Ranking the whole MEDLINE database according to a large training set using text indexing
Background: The MEDLINE database contains over 12 million references to scientific literature, ut 3/4 of recent articles including an abstract of the publication. Retrieval of ent...
Brian P. Suomela, Miguel A. Andrade
BMCBI
2005
135views more  BMCBI 2005»
15 years 6 months ago
A robust two-way semi-linear model for normalization of cDNA microarray data
Background: Normalization is a basic step in microarray data analysis. A proper normalization procedure ensures that the intensity ratios provide meaningful measures of relative e...
Deli Wang, Jian Huang, Hehuang Xie, Liliana Manzel...
BMCBI
2005
169views more  BMCBI 2005»
15 years 6 months ago
An adaptive method for cDNA microarray normalization
Background: Normalization is a critical step in analysis of gene expression profiles. For duallabeled arrays, global normalization assumes that the majority of the genes on the ar...
Yingdong Zhao, Ming-Chung Li, Richard Simon
BMCBI
2005
94views more  BMCBI 2005»
15 years 6 months ago
Reproducible Clusters from Microarray Research: Whither?
Motivation: In cluster analysis, the validity of specific solutions, algorithms, and procedures present significant challenges because there is no null hypothesis to test and no &...
Nikhil R. Garge, Grier P. Page, Alan P. Sprague, B...
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