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BMCBI
2006
126views more  BMCBI 2006»
15 years 6 months ago
A joint model of regulatory and metabolic networks
Background: Gene regulation and metabolic reactions are two primary activities of life. Although many works have been dedicated to study each system, the coupling between them is ...
Chen-Hsiang Yeang, Martin Vingron
BMCBI
2004
106views more  BMCBI 2004»
15 years 6 months ago
Spotting effect in microarray experiments
Background: Microarray data must be normalized because they suffer from multiple biases. We have identified a source of spatial experimental variability that significantly affects...
Tristan Mary-Huard, Jean-Jacques Daudin, Sté...
BMCBI
2004
150views more  BMCBI 2004»
15 years 6 months ago
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila
Background: The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quanti...
Saurabh Sinha, Mark D. Schroeder, Ulrich Unnerstal...
RECOMB
2010
Springer
16 years 1 months ago
Hierarchical Generative Biclustering for MicroRNA Expression Analysis
Clustering methods are a useful and common first step in gene expression studies, but the results may be hard to interpret. We bring in explicitly an indicator of which genes tie ...
José Caldas, Samuel Kaski
BMCBI
2011
15 years 1 months ago
Empirical Bayesian models for analysing molecular serotyping microarrays
Background: Microarrays offer great potential as a platform for molecular diagnostics, testing clinical samples for the presence of numerous biomarkers in highly multiplexed assay...
Richard Newton, Jason Hinds, Lorenz Wernisch