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BMCBI
2010
160views more  BMCBI 2010»
15 years 7 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian
BMCBI
2008
114views more  BMCBI 2008»
15 years 7 months ago
Dinucleotide controlled null models for comparative RNA gene prediction
Background: Comparative prediction of RNA structures can be used to identify functional noncoding RNAs in genomic screens. It was shown recently by Babak et al. [BMC Bioinformatic...
Tanja Gesell, Stefan Washietl
BMCBI
2008
93views more  BMCBI 2008»
15 years 7 months ago
Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations
Background: Structure-based computational methods are needed to help identify and characterize protein-protein complexes and their function. For individual proteins, the most succ...
Guillaume Launay, Thomas Simonson
BMCBI
2006
86views more  BMCBI 2006»
15 years 7 months ago
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution
Background: Non-coding DNA sequences comprise a very large proportion of the total genomic content of mammals, most other vertebrates, many invertebrates, and most plants. Unravel...
Jun Wang, Peter D. Keightley, Toby Johnson
BMCBI
2006
130views more  BMCBI 2006»
15 years 7 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...