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BMCBI
2008
84views more  BMCBI 2008»
15 years 6 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2008
103views more  BMCBI 2008»
15 years 6 months ago
Parameter estimation for robust HMM analysis of ChIP-chip data
Background: Tiling arrays are an important tool for the study of transcriptional activity, proteinDNA interactions and chromatin structure on a genome-wide scale at high resolutio...
Peter Humburg, David Bulger, Glenn Stone
BMCBI
2005
149views more  BMCBI 2005»
15 years 6 months ago
The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional pre
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
Jan Kosinski, Marcin Feder, Janusz M. Bujnicki
JSS
2007
115views more  JSS 2007»
15 years 6 months ago
A case study in re-engineering to enforce architectural control flow and data sharing
Without rigorous software development and maintenance, software tends to lose its original architectural structure and become difficult to understand and modify. ArchJava, a recen...
Marwan Abi-Antoun, Jonathan Aldrich, Wesley Coelho
COMCOM
2004
138views more  COMCOM 2004»
15 years 6 months ago
Issues with inferring Internet topological attributes
A number of recent studies of Internet network structure are based on data collected from inter-domain BGP routing tables and tools, such as traceroute, to probe end-to-end paths....
Lisa Amini, Anees Shaikh, Henning Schulzrinne