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170
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BMCBI
2004
15 years 6 months ago
2004
Background: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUS...
187
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BMCBI
2004
15 years 6 months ago
2004
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
200
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BMCBI
2004
15 years 6 months ago
2004
Background: DopaNet http://www.dopanet.org is a Systems Biology initiative that aims to investigate precisely and quantitatively all the aspects of neurotransmission in a specific...
148
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BMCBI
2004
15 years 6 months ago
2004
Background: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) d...
172
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BMCBI
2004
15 years 6 months ago
2004
Background: Profile Hidden Markov Models (pHMMs) are a widely used tool for protein family research. Up to now, however, there exists no method to visualize all of their central a...