Background: The relationship between disease susceptibility and genetic variation is complex, and many different types of data are relevant. We describe a web resource and databas...
Background: A key post genomics challenge is to identify how genes in an organism come together and perform physiological functions. An important first step in this direction is t...
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Background: The development of high-throughput technologies has produced several large scale protein interaction data sets for multiple species, and significant efforts have been ...
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...