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BMCBI
2007
102views more  BMCBI 2007»
15 years 6 months ago
Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties
Background: Homology is a key concept in both evolutionary biology and genomics. Detection of homology is crucial in fields like the functional annotation of protein sequences and...
Jos Boekhorst, Berend Snel
BMCBI
2008
128views more  BMCBI 2008»
15 years 6 months ago
HAPSIMU: a genetic simulation platform for population-based association studies
Background: Population structure is an important cause leading to inconsistent results in population-based association studies (PBAS) of human diseases. Various statistical method...
Feng Zhang, Jianfeng Liu, Jie Chen, Hong-Wen Deng
BMCBI
2007
140views more  BMCBI 2007»
15 years 6 months ago
Investigations into the relationship between feedback loops and functional importance of a signal transduction network based on
Background: A number of studies on biological networks have been carried out to unravel the topological characteristics that can explain the functional importance of network nodes...
Yung-Keun Kwon, Sun Shim Choi, Kwang-Hyun Cho
BMCBI
2008
98views more  BMCBI 2008»
15 years 6 months ago
Assessing probe-specific dye and slide biases in two-color microarray data
Background: A primary reason for using two-color microarrays is that the use of two samples labeled with different dyes on the same slide, that bind to probes on the same spot, is...
Ruixiao Lu, Geun-Cheol Lee, Michael Shultz, Chris ...
BMCBI
2008
82views more  BMCBI 2008»
15 years 6 months ago
Envelope: interactive software for modeling and fitting complex isotope distributions
Background: An important aspect of proteomic mass spectrometry involves quantifying and interpreting the isotope distributions arising from mixtures of macromolecules with differe...
Michael T. Sykes, James R. Williamson
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