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BMCBI
2004
177views more  BMCBI 2004»
15 years 6 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
180
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GCB
2009
Springer
154views Biometrics» more  GCB 2009»
15 years 10 months ago
Comparative Identification of Differential Interactions from Trajectories of Dynamic Biological Networks
Abstract: It is often challenging to reconstruct accurately a complete dynamic biological network due to the scarcity of data collected in cost-effective experiments. This paper ad...
Zhengyu Ouyang, Mingzhou Song
WSC
2008
15 years 9 months ago
How to build valid and credible simulation models
In this tutorial we present techniques for building valid and credible simulation models. Ideas to be discussed include the importance of a definitive problem formulation, discuss...
Averill M. Law
BMCBI
2010
124views more  BMCBI 2010»
15 years 6 months ago
A factor model to analyze heterogeneity in gene expression
Background: Microarray technology allows the simultaneous analysis of thousands of genes within a single experiment. Significance analyses of transcriptomic data ignore the gene d...
Yuna Blum, Guillaume Le Mignon, Sandrine Lagarrigu...
COLING
2008
15 years 8 months ago
An Integrated Probabilistic and Logic Approach to Encyclopedia Relation Extraction with Multiple Features
We propose a new integrated approach based on Markov logic networks (MLNs), an effective combination of probabilistic graphical models and firstorder logic for statistical relatio...
Xiaofeng Yu, Wai Lam