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ACL
2006
15 years 7 months ago
Semi-Supervised Conditional Random Fields for Improved Sequence Segmentation and Labeling
We present a new semi-supervised training procedure for conditional random fields (CRFs) that can be used to train sequence segmentors and labelers from a combination of labeled a...
Feng Jiao, Shaojun Wang, Chi-Hoon Lee, Russell Gre...
ICCAD
2009
IEEE
147views Hardware» more  ICCAD 2009»
15 years 4 months ago
SAT-based protein design
Computational protein design can be formulated as an optimization problem, where the objective is to identify the sequence of amino acids that minimizes the energy of a given prot...
Noah Ollikainen, Ellen Sentovich, Carlos Coelho, A...
BMCBI
2008
128views more  BMCBI 2008»
15 years 6 months ago
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Christopher Bystroff, Bobbie-Jo M. Webb-Robertson
ALMOB
2008
81views more  ALMOB 2008»
15 years 6 months ago
Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family
Background: Sequence-based phylogeny reconstruction is a fundamental task in Bioinformatics. Practically all methods for phylogeny reconstruction are based on multiple alignments....
Holger Wagner, Burkhard Morgenstern, Andreas W. M....
BMCBI
2008
158views more  BMCBI 2008»
15 years 6 months ago
Metrics for GO based protein semantic similarity: a systematic evaluation
Background: Several semantic similarity measures have been applied to gene products annotated with Gene Ontology terms, providing a basis for their functional comparison. However,...
Catia Pesquita, Daniel Faria, Hugo P. Bastos, Ant&...