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» Shotgun Protein Sequencing
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BMCBI
2010
131views more  BMCBI 2010»
15 years 6 months ago
FACT: Functional annotation transfer between proteins with similar feature architectures
Background: The increasing number of sequenced genomes provides the basis for exploring the genetic and functional diversity within the tree of life. Only a tiny fraction of the e...
Tina Koestler, Arndt von Haeseler, Ingo Ebersberge...
BMCBI
2007
109views more  BMCBI 2007»
15 years 6 months ago
Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint
Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initi...
Russell L. Marsden, Tony A. Lewis, Christine A. Or...
BMCBI
2006
111views more  BMCBI 2006»
15 years 6 months ago
Development of an unbiased statistical method for the analysis of unigenic evolution
Background: Unigenic evolution is a powerful genetic strategy involving random mutagenesis of a single gene product to delineate functionally important domains of a protein. This ...
Colleen D. Behrsin, Chris J. Brandl, David W. Litc...
BMCBI
2006
103views more  BMCBI 2006»
15 years 6 months ago
Domain-based small molecule binding site annotation
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
Kevin A. Snyder, Howard J. Feldman, Michel Dumonti...
NAR
2006
74views more  NAR 2006»
15 years 6 months ago
NOPdb: Nucleolar Proteome Database
The Nucleolar Proteome Database (NOPdb) archives data on .700 proteins that were identified by multiple mass spectrometry (MS) analyses from highly purified preparations of human ...
Anthony Kar Lun Leung, Laura Trinkle-Mulcahy, Yun ...