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BMCBI
2006
125views more  BMCBI 2006»
15 years 6 months ago
Automated functional classification of experimental and predicted protein structures
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...
Kai Wang, Ram Samudrala
BMCBI
2006
143views more  BMCBI 2006»
15 years 6 months ago
IsoSVM - Distinguishing isoforms and paralogs on the protein level
Background: Recent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred...
Michael Spitzer, Stefan Lorkowski, Paul Cullen, Al...
CSWWS
2006
15 years 10 months ago
A Distributed Agent System upon Semantic Web Technologies to Provide Biological Data
Bioinformaticians are accustomed to going through analysis steps, in which they employ several data sources, like protein sequence and protein interaction databases, to carry out t...
Farzad Kohantorabi, Gregory Butler, Christopher J....
BMCBI
2008
86views more  BMCBI 2008»
15 years 6 months ago
Subfamily specific conservation profiles for proteins based on n-gram patterns
Background: A new algorithm has been developed for generating conservation profiles that reflect the evolutionary history of the subfamily associated with a query sequence. It is ...
John K. Vries, Xiong Liu
BMCBI
2006
117views more  BMCBI 2006»
15 years 6 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala