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BMCBI
2010
98views more  BMCBI 2010»
15 years 6 months ago
Resolving anaphoras for the extraction of drug-drug interactions in pharmacological documents
Background: Drug-drug interactions are frequently reported in the increasing amount of biomedical literature. Information Extraction (IE) techniques have been devised as a useful ...
Isabel Segura-Bedmar, Mario Crespo, César d...
BMCBI
2010
160views more  BMCBI 2010»
15 years 6 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
BMCBI
2008
142views more  BMCBI 2008»
15 years 6 months ago
Genetic weighted k-means algorithm for clustering large-scale gene expression data
Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
Fang-Xiang Wu
BMCBI
2008
92views more  BMCBI 2008»
15 years 6 months ago
Proteochemometric modeling of HIV protease susceptibility
Background: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated ...
Maris Lapinsh, Martin Eklund, Ola Spjuth, Peteris ...
BMCBI
2007
174views more  BMCBI 2007»
15 years 6 months ago
Inferring activity changes of transcription factors by binding association with sorted expression profiles
Background: The identification of transcription factors (TFs) associated with a biological process is fundamental to understanding its regulatory mechanisms. From microarray data,...
Chao Cheng, Xiting Yan, Fengzhu Sun, Lei M. Li
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