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BMCBI
2006
119views more  BMCBI 2006»
15 years 6 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
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BMCBI
2006
102views more  BMCBI 2006»
15 years 6 months ago
Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of
Background: The Thymidine kinase (Tk) mutants generated from the widely used L5178Y mouse lymphoma assay fall into two categories, small colony and large colony. Cells from the la...
Tao Han, Jianyong Wang, Weida Tong, Martha M. Moor...
BMCBI
2006
116views more  BMCBI 2006»
15 years 6 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
BMCBI
2006
223views more  BMCBI 2006»
15 years 6 months ago
PSMIX: an R package for population structure inference via maximum likelihood method
Background: Inference of population stratification and individual admixture from genetic markers is an integrative part of a study in diverse situations, such as association mappi...
Baolin Wu, Nianjun Liu, Hongyu Zhao
BMCBI
2007
130views more  BMCBI 2007»
15 years 6 months ago
Differential analysis for high density tiling microarray data
Background: High density oligonucleotide tiling arrays are an effective and powerful platform for conducting unbiased genome-wide studies. The ab initio probe selection method emp...
Srinka Ghosh, Heather A. Hirsch, Edward A. Sekinge...