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BMCBI
2010
147views more  BMCBI 2010»
15 years 6 months ago
CNstream: A method for the identification and genotyping of copy number polymorphisms using Illumina microarrays
Background: Understanding the genetic basis of disease risk in depth requires an exhaustive knowledge of the types of genetic variation. Very recently, Copy Number Variants (CNVs)...
Arnald Alonso, Antonio Julià, Raül Tor...
BMCBI
2010
131views more  BMCBI 2010»
15 years 6 months ago
JISTIC: Identification of Significant Targets in Cancer
Background: Cancer is caused through a multistep process, in which a succession of genetic changes, each conferring a competitive advantage for growth and proliferation, leads to ...
Felix Sanchez-Garcia, Uri David Akavia, Eyal Mozes...
BMCBI
2010
93views more  BMCBI 2010»
15 years 6 months ago
Hybridization thermodynamics of NimbleGen Microarrays
Background: While microarrays are the predominant method for gene expression profiling, probe signal variation is still an area of active research. Probe signal is sequence depend...
Ulrike Mückstein, Germán G. Leparc, Al...
BMCBI
2010
158views more  BMCBI 2010»
15 years 6 months ago
Validation of differential gene expression algorithms: Application comparing fold-change estimation to hypothesis testing
Background: Sustained research on the problem of determining which genes are differentially expressed on the basis of microarray data has yielded a plethora of statistical algorit...
Corey M. Yanofsky, David R. Bickel
BMCBI
2010
136views more  BMCBI 2010»
15 years 6 months ago
SCPS: a fast implementation of a spectral method for detecting protein families on a genome-wide scale
Background: An important problem in genomics is the automatic inference of groups of homologous proteins from pairwise sequence similarities. Several approaches have been proposed...
Tamás Nepusz, Rajkumar Sasidharan, Alberto ...
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