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» Representations of Metabolic Knowledge
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BMCBI
2006
89views more  BMCBI 2006»
15 years 6 months ago
ORENZA: a web resource for studying ORphan ENZyme activities
Background: Despite the current availability of several hundreds of thousands of amino acid sequences, more than 36% of the enzyme activities (EC numbers) defined by the Nomenclat...
Olivier Lespinet, Bernard Labedan
BMCBI
2007
102views more  BMCBI 2007»
15 years 6 months ago
qPIPSA: Relating enzymatic kinetic parameters and interaction fields
Background: The simulation of metabolic networks in quantitative systems biology requires the assignment of enzymatic kinetic parameters. Experimentally determined values are ofte...
Razif R. Gabdoulline, Matthias Stein, Rebecca C. W...
JAIR
2008
157views more  JAIR 2008»
15 years 6 months ago
Qualitative System Identification from Imperfect Data
Experience in the physical sciences suggests that the only realistic means of understanding complex systems is through the use of mathematical models. Typically, this has come to ...
George Macleod Coghill, Ashwin Srinivasan, Ross D....
BMCBI
2005
98views more  BMCBI 2005»
15 years 6 months ago
Iterative approach to model identification of biological networks
Background: Recent advances in molecular biology techniques provide an opportunity for developing detailed mathematical models of biological processes. An iterative scheme is intr...
Kapil G. Gadkar, Rudiyanto Gunawan, Francis J. Doy...
BMCBI
2005
118views more  BMCBI 2005»
15 years 6 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz