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BMCBI
2006
98views more  BMCBI 2006»
15 years 6 months ago
In search of functional association from time-series microarray data based on the change trend and level of gene expression
Background: The increasing availability of time-series expression data opens up new possibilities to study functional linkages of genes. Present methods used to infer functional l...
Feng He, An-Ping Zeng
BMCBI
2006
161views more  BMCBI 2006»
15 years 6 months ago
A novel approach to phylogenetic tree construction using stochastic optimization and clustering
Background: The problem of inferring the evolutionary history and constructing the phylogenetic tree with high performance has become one of the major problems in computational bi...
Ling Qin, Yixin Chen, Yi Pan, Ling Chen
BMCBI
2006
128views more  BMCBI 2006»
15 years 6 months ago
Lexical adaptation of link grammar to the biomedical sublanguage: a comparative evaluation of three approaches
Background: We study the adaptation of Link Grammar Parser to the biomedical sublanguage with a focus on domain terms not found in a general parser lexicon. Using two biomedical c...
Sampo Pyysalo, Tapio Salakoski, Sophie Aubin, Adel...
BMCBI
2006
165views more  BMCBI 2006»
15 years 6 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig
BMCBI
2006
153views more  BMCBI 2006»
15 years 6 months ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...