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» Reconstructing the pre-doubling genome
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BMCBI
2011
15 years 1 months ago
Using Stochastic Causal Trees to Augment Bayesian Networks for Modeling eQTL Datasets
Background: The combination of genotypic and genome-wide expression data arising from segregating populations offers an unprecedented opportunity to model and dissect complex phen...
Kyle C. Chipman, Ambuj K. Singh
RECOMB
2012
Springer
13 years 8 months ago
Recovering the Tree-Like Trend of Evolution Despite Extensive Lateral Genetic Transfer: A Probabilistic Analysis
Abstract. Lateral gene transfer (LGT) is a common mechanism of nonvertical evolution where genetic material is transferred between two more or less distantly related organisms. It ...
Sebastien Roch, Sagi Snir
CEC
2008
IEEE
16 years 14 days ago
A self-adaptive cellular memetic algorithm for the DNA fragment assembly problem
Abstract— The DNA fragment assembly problem is to reconstruct a DNA chain from multiple fragments that have previously been sequenced in a laboratory. This is a critical step in ...
Bernabé Dorronsoro, Enrique Alba, Gabriel L...
GECCO
2007
Springer
131views Optimization» more  GECCO 2007»
16 years 5 days ago
Using feedback to regulate gene expression in a developmental control architecture
We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developme...
Kester Clegg, Susan Stepney, Tim Clarke
TCBB
2008
122views more  TCBB 2008»
15 years 5 months ago
Mixed Integer Linear Programming for Maximum-Parsimony Phylogeny Inference
Reconstruction of phylogenetic trees is a fundamental problem in computational biology. While excellent heuristic methods are available for many variants of this problem, new adva...
Srinath Sridhar, Fumei Lam, Guy E. Blelloch, R. Ra...